Probability, Evidential Support, and the Logic of Conditionals

Once upon a time, some thought that indicative conditionals could be effectively analyzed as material conditionals. Later on, an alternative theoretical construct has prevailed and received wide acceptance, namely, the conditional probability of the consequent given the antecedent. Partly following critical remarks recently ap- peared in the literature, we suggest that evidential support—rather than conditional probability alone—is key to understand indicative conditionals. There have been motivated concerns that a theory of evidential conditionals (unlike their more tra- ditional counterparts) cannot generate a sufficiently interesting logical system. Here, we will describe results dispelling these worries. Happily, and perhaps surprisingly, appropriate technical variations of Ernst Adams’s classical approach allow for the construction of a logic of evidential conditionals with distinctive fea- tures, which is also well-behaved and reasonably strong

Fatalism and Future Contingents

In this paper I address issues related to the problem of future contingents and the metaphysical doctrine of fatalism. Two classical responses to the problem of future contingents are the third truth value view and the all-false view. According to the former, future contingents take a third truth value which goes beyond truth and falsity. According to the latter, they are all false. I here illustrate and discuss two ways to respectively argue for those two views. Both ways are similar in spirit and intimately connected with fatalism, in the sense that they engage with the doctrine of fatalism and accept a large part of a standard fatalistic machinery

Embriogenesi e malformazioni dell’apparato urinario e genitale maschile

Non previsto perché trattasi di capitolo di libr

I tumori del rene

non presente (capitolo di libro

Quality and antioxidant traits of organic apricots (Prunus armeniaca L.) at harvest and after storage

In recent years, consumers are interested in low-input agricultural practices and healthy foods. The aim of this research was to assess the pomological quality and antioxidant properties of organic apricot fruits from several cultivars which have been previously evaluated under integrated cultivation. Apricot quality after cold storage (14 days at 4±0.5°C, 90% relative humidity) was also tested in order to evaluate the fruit storability. Fruits from seven Italian apricot cultivars (Prunus armeniaca L.), grown under organic management system, were analyzed according to the main physicochemical traits, total antioxidant activity (TAC) and total phenols content (TP). Organic practices did not always have a significant influence on the major fruit quality attributes. Three out of seven genotypes positively responded to organic management showing, in particular, higher TAC and TP levels than integrated apricot fruits. Moreover, the capacity to keep unchanged the physicochemical and antioxidant properties of fruits after storage was an interesting result considering the high susceptibility of fresh apricots to conservation. The maintenance of high quality parameters could be an added-value for organic apricot productions. In conclusion, this study provides new perspectives for organically grown apricots, confirming the importance of the cultivar’s choice in order to obtain the best quality performances, in agreement to researches establishing as the genotype may influence more than any other parameters the fruit quality characteristics

The Invisible Thin Red Line

The aim of this paper is to argue that the adoption of an unrestricted principle of bivalence is compatible with a metaphysics that (i) denies that the future is real, (ii) adopts nomological indeterminism, and (iii) exploits a branching structure to provide a semantics for future contingent claims. To this end, we elaborate what we call Flow Fragmentalism, a view inspired by Kit Fine (2005)’s non-standard tense realism, according to which reality is divided up into maximally coherent collections of tensed facts. In this way, we show how to reconcile a genuinely A-theoretic branching-time model with the idea that there is a branch corresponding to the thin red line, that is, the branch that will turn out to be the actual future history of the world

miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer

This work is licensed under a Creative Commons Attribution 4.0 International License.Elevated prostaglandin E2 (PGE2) levels are observed in colorectal cancer (CRC) patients, and this increase is associated with poor prognosis. Increased synthesis of PGE2 in CRC has been shown to occur through COX-2-dependent mechanisms; however, loss of the PGE2-catabolizing enzyme, 15-hydroxyprostaglandin dehydrogenase (15-PGDH, HPGD), in colonic tumors contributes to increased prostaglandin levels and poor patient survival. While loss of 15-PGDH can occur through transcriptional mechanisms, we demonstrate that 15-PGDH can be additionally regulated by a miRNA-mediated mechanism. We show that 15-PGDH and miR-21 are inversely correlated in CRC patients, with increased miR-21 levels associating with low 15-PGDH expression. 15-PGDH can be directly regulated by miR-21 through distinct sites in its 3′ untranslated region (3′UTR), and miR-21 expression in CRC cells attenuates 15-PGDH and promotes increased PGE2 levels. Additionally, epithelial growth factor (EGF) signaling suppresses 15-PGDH expression while simultaneously enhancing miR-21 levels. miR-21 inhibition represses CRC cell proliferation, which is enhanced with EGF receptor (EGFR) inhibition. These findings present a novel regulatory mechanism of 15-PGDH by miR-21, and how dysregulated expression of miR-21 may contribute to loss of 15-PGDH expression and promote CRC progression via increased accumulation of PGE2.NIH R01 CA134609NIH R01 AR069044NIH/NCI Cancer Center Support Grant (P30 CA168524)New Jersey Commission on Cancer ResearchAmerican Heart Association (15GRNT23240019

Application of Ambulatory Phonation Monitoring (APM) in the measurement of daily speaking-time and voice intensity before and after cochlear implant in deaf adult patients

Objective: to evaluate the changes in daily voice production, analysed through the Ambulatory Phonation Monitoring (APM), and their relationship with Quality of Life (QOL) measurements in a group of profound deaf patients treated with Cochlear Implant (CI). Methods: A total of 12 consecutive post-lingual deaf patients (8 females and 4 males) treated with CI for bilateral severe-to-profound hearing loss were enrolled. Each patient was evaluated before and after 6 months of CI use. In particular, the daily voice production evaluation was performed using the APM, while QOL information were gathered from the Italian version of the Nijmegen Cochlear Implant Questionnaire (I-NCIQ). Results: Significant differences in the APM results obtained before and after CI were found. In particular, a significant decrease of the mean amplitude and a significant increase of the daily phonation time and percentage of phonation time were demonstrated after CI use in all the patients. A significant improvement in the I-NCIQ scores was demonstrated after CI use and significant correlations among I-NCIQ scores and the APM parameters were found. Conclusions: The APM could be useful in the evaluation of the benefits of cochlear implantation and may represents an indicator of deaf patient participation. In addition, the daily voice production's modifications after CI and their significant relations with the changes in QOL measurements could be useful in treatment planning as well as during pre- and post-operative counselling

Independent validation of sepsis index for sepsis screening in the emergency department

(1) Background: The early detection of sepsis is still challenging, and there is an urgent need for biomarkers that could identify patients at a high risk of developing it. We recently developed an index, namely the Sepsis Index (SI), based on the combination of two CBC parameters: monocyte distribution width (MDW) and mean monocyte volume (MMV). In this study, we sought to independently validate the performance of SI as a tool for the early detection of patients at a high risk of sepsis in the Emergency Department (ED). (2) Methods: We enrolled all consecutive patients attending the ED with a request of the CBC. MDW and MMV were measured on samples collected in K3-EDTA tubes on the UniCel DxH 900 haematology analyser. SI was calculated based on the MDW and MMV. (3) Results: We enrolled a total of 703 patients stratified into four subgroups according to the Sepsis-2 criteria: control (498), infection (105), SIRS (52) and sepsis (48). The sepsis subgroup displayed the highest MDW (median 27.5, IQR 24.6–32.9) and SI (median 1.15, IQR 1.05–1.29) values. The ROC curve analysis for the prediction of sepsis showed a good and comparable diagnostic accuracy of the MDW and SI. However, the SI displayed an increased specificity, positive predictive value and positive likelihood ratio in comparison to MDW alone. (4) Conclusions: SI improves the diagnostic accuracy of MDW for sepsis screening